The genetic polymorphisms of N-acetyltransferase 1 and the genetic susceptibility to primary liver cancer in Luoyang, China / 中国癌症杂志

ABSTRACT

Purpose:To assess the association between the genetic polymorphisms of N-acetyltransferase1 (NAT 1) and the susceptibility to primary liver cancer (PLC). Methods:The NAT1 genotypes of 96 PLC cases and 173 controls were detected with polymerase chain reaction followed by restriction fragment length polymorphism. And the interactions between NAT1 and environmental risk factors were also analyzed. Results:In PLC cases, the frequencies of NAT1 *3, NAT1 *4, NAT1 *10 and NAT1 *14B were 20.3%, 50.5%, 24.0% and 5.2%, respectively. The frequencies of NAT1 *3/ *3, NAT1 *3/ *4, NAT1 *3/ *10, NAT1 *3/ *14B, NAT1 *4/ *4, NAT1 *4/ *10, NAT1 *4/ *14B, NAT1 *10 / *10 and NAT1 *10/ *14B genotypes were 4.2%, 25.0%, 3.1%, 4.2%, 31.3%, 10.4%, 3.1%, 14.7 and 4.2%, respectively. No statistically significant difference of the frequencies was found between the two groups. In PLC cases, the frequencies of rapid type NAT1 and slow type NAT1 were 32.3% and 67.7% respectively, which had no statistically significant difference compared with the control group. The interaction between NAT1 *10 and occupational exposures was found with an odds ratio of 3.40(95%CI1.03～11.22). Conclusions:There is no relation between genetic polymorphisms of NAT1 and PLC. NAT1 *10 interacts with occupational exposures.