Changes of serum pituitary hormones and thyroid hormones in patients with severe brain injuries in response to mild hypothermia / 中华创伤杂志

ABSTRACT

Objective To investigate the changes of serum pituitary hormones and thyroid hormones in patients with severe brain injuries during hypothermia therapy. Methods Ninety-eight patients with severe brain injuries were randomly divided into mild hypothermia group (50 cases) and control group (routine therapy group,48 cases). The levels of serum PRL,TSH,FT 3 and FT 4 of patients in the both groups were detected by two-side sandwich immunological autochemoluminescence detection system before and after treatment. The therapeutic effects were observed and compared. Results After treatment,the levels of serum PRL,TSH and FT 4 of patients in hypothermia group were (0.25? 0.02) nmol/L ,(0.7?0.2) mU/L and (15.0?5.3) pmol/L,respectively,which were significantly lower than that in control group,ie,(0.46?0.04) nmol/L,(1.1?0.3) mU/L and (21.2? 6.4) pmol/L ,respectively. The good recovery rate (62%) in hypothermia group was higher than that of control group (35%) but the death rate (22%) in hypothermia group was lower than that of control group (42%). Conclusions Mild hypothermia can inhibit the rise of serum pituitary hormones and thyroid hormones after severe brain injury and improve the therapeutic effects.