Protective effect of glucocorticoid-free immunosuppressive regimen on allogenic islet transplantation / 中华器官移植杂志
Chinese Journal of Organ Transplantation
;
(12)1996.
Article
in Chinese
| WPRIM
| ID: wpr-539896
ABSTRACT
Objective To evaluate the effect of anti-rejection of glucocorticoid-free immunosuppressive regimen on allogenic islet transplantation.Methods Tacrolimus (FK506)+ mycophenolate mofetil (MMF) and FK506+MMF+prednisone (Pred) were administered respectively for two weeks to inhibit rejection after allogenic islet transplantation in rats,which were compared with control group. The concentrations of blood glucose,insulin and C-peptide were determined dynamically in recipients and the sites of transplantation were observed morphologically.Results As compared with control group without immunosuppressive agents,FK506+MMF and FK506+MMF+Pred could prolong the survival time of grafts significantly. There were many morphologically intact islets in liver of recipients two months after transplantation. Group FK506+MMF kept normal blood glucose,insulin and C-peptide beyond 60 days after transplantation,but compared with the former,group FK506+MMF+Pred secreted less C-peptide ( P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Organ Transplantation
Year:
1996
Type:
Article
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