Association of interleukin-1?, 4, 6, TNF-? gene polymorphisms with Hashimoto′s thyroiditis / 中华内分泌代谢杂志

ABSTRACT

The association of the polymorphisms of interleukin (IL)-1?, IL-4, IL-6, tumor necrosis factor-? (TNF-?) gene with Hashimoto′s thyroiditis (HT) in Shandong population of China was investigated. The results showed that the frequency of the t allele in the promoter region of IL-4 at position -590 in HT group was significantly lower than that in control group (0.060 vs 0.155, P