Combination chemotherapy with navelbine(NVB) and epirubicin( e-ADM )in treating metastatic breast cancer / 中国癌症杂志

ABSTRACT

Purpose:To investigate the therapeutic effect a nd toxicity of combination chemotherapy with navelbine (NVB) and epirubicin (E- ADM) in treating metastatic breast cancer. Methods:37 patients with metastatic breast cancer were treated with combination chemotherapy of vinorelbine 25 mg/m2 d 1.8, E-ADM 60 mg/m2 d 1, 21 days for a cycle, a total of 2-4 cycles, made tracks for 6-37 months. Results:Among 27 patients with 37 metastatis, CR was 37.84%(14/ 37), PR 16.22%(6/37), SD 37.83%(14/37), SD≥6 months,21.62%(8/37), PD8.11%(3/37) , ORR(CR+PR) 54.05%, (CR+PR+SD≥6 months) 75.68%, and TTP was 6-9 months. Th e peak value of the efficiency to the lymph metastasis above the clavicle was 90 .9%. The toxicity was leukopenia,losing hair,milieu phlebitis. 74.07% of cases was in Grade Ⅲ and Grade Ⅳ leukopenia , 11.11% of cases was phlebitis. Conclusions:The combination chemotherapy with navelbine(NVB) an d epirubicin (E-ADM) in treating metastatic breast canser is effective and has acceptable tolerance.