Prognostic effect of cyclooxygenase-2 in non-small-cell lung cancer / 中国癌症杂志

ABSTRACT

Purpose:To investigate prognostic effects of ex pressions of cyclooxygenase-2(COX-2) and epidermal growth factor receptor(EGFR )in non-small-cell lung cancer(NSCLC).Methods:Expression of COX-2 and EGFR in the resected tumors of 60 patients with NSCLC were detected with the method of immunohistochemistry st aining.We used ?2 test and COX regression analysis to compare difference in e xpressions of COX-2 and EGFR in differentiation grade of squamous and adeno-ca rcinoma cells of the lungs and their relationships with the patients survival in NSCLC.Results:The positive rates for COX-2 were 73% and 33% in adeno carcinoma and squamous carcinoma,respectively.The expression rate was significan tly higher in the adenocarcinoma than in the squamous carcinoma.Expressions of C OX-2 and EGFR in NSCLC were not related to patientsage and sex,differentiation grade of tumor cells,TNM staging,size of promary tumor and lymph nodes metastasi s.Median survival time was 30 months and 16 months in COX-2 expression levels o f “+” and of “++”,34 months and 15 months in EGFR expression levels of “+” and of “++” and was significantly lower than in those without expression of C OX-2 or EGFR(P