Expression and correlation of E-cadherin and CD44V6 in oral squamous cell carcinoma / 实用口腔医学杂志

ABSTRACT

Objective:To study the expressions of E-cadherin(E-cad) an d CD44V6 in normal oral mucous,oral atypical hyperplasia and oral squamous cell carcinoma(OSCC).Methods:The expression of E-cad and CD44V6 in 1 7 cases of normal oral mucous,6 of oral atypical hyperplasia and 52 of OSCC was examined with immunohistochemistry. Results: E-cad expression was observed in all the cases of normal oral mucous and oral atypical hyperplasi a,and in 43/52( 82.69% ) of OSCC. CD44V6 expression was observed in all the ca ses of normal oral mucous and oral atypical hyperplasia,and in 32/52(61.54%) of OSCC.In OSCC, the expression of E-cad was decreased with the decrease of differ entiation degree(P