The expression of P-gp, GST-? and TopoⅡ in breast cancer and their clinical significance / 肿瘤研究与临床
Cancer Research and Clinic
;
(6)2000.
Article
in Chinese
| WPRIM
| ID: wpr-540777
ABSTRACT
Objective To investigate the expression and their clinical significance of P?- glycoprotein (P?- gp), glutathione?- S?- transferase?- ?(GST?- ?)and DNA topoisomerase Ⅱ(TopoⅡ)in breast cancer. Methods The expressions of P?- gp, GST?- ? and TopoⅡ were detected in 60 cases of untreated primary breast cancer by using immunohistochemical S?- P method. Results The positive expression rates of P?- gp, GST?- ? and TopoⅡ in breast cancer were 37.1 %, 66.7 % and 55.0 % respectively. The expression of P?- gp and TopoⅡ had positive correlation with degree of differentiation(P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Cancer Research and Clinic
Year:
2000
Type:
Article
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