The effect of focal cerebral ischemic preconditioning on brain edema and the expression of NF-?B and its target gene MMP-9 in rats / 中华老年医学杂志
Chinese Journal of Geriatrics
; (12)2001.
Article
in Zh
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| ID: wpr-540866
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ABSTRACT
Objective To investigate the effect of focal cerebral ischemic preconditioning (IPC) on brain edema and the expression of nuclear factor-?B( NF-?B) and its target gene MMP-9. Methods Forty-five SD rats were divided into 3 groups in which control group received sham surgery only, and the other two groups received 2 hours of middle cerebral artery occlusion (MCAO) followed by 22 hours of reperfusion with or without 10 minutes of IPC 3 days before. Brain water content, expression of NF-?B and MMP-9 mRNA were evaluated in each group by wet-dry weight method, immunohistochemistry staining and RT-PCR. Results Compared with the SS group, there was a lower NF-?B immunoreactivity and MMP-9 mRNA level (16 098.2?1 265.3 vs 23 565.8?1 978.4,50.7% vs 84.1%, P
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Geriatrics
Year:
2001
Type:
Article