Expression of TLR4 and TLR2 mRNA in the peripheral blood mononuclear cells of the patients with Gram negative or Gram positive infections / 中国免疫学杂志
Chinese Journal of Immunology
; (12)1986.
Article
in Zh
| WPRIM
| ID: wpr-541046
Responsible library:
WPRO
ABSTRACT
Objective:To investigate the expression of TLR4 mRNA?TLR2 mRNA in the peripheral blood mononuclear cells (PBMC) from the patients with Gram positive and Gram negative infections.Methods:TLR4 and TLR2 mRNA were detected in the patients with Gram negative infections ( n =20) and the patients with Gram positive infections ( n =15) and the normal persons as control ( n =24) with the method of Taqman Real-time PCR.Results:TLR4 mRNA expression in the patients with Gram negative infections were significantly higher than Gram positive infections patients and the normals ( P 0.05).Conclusion:The results showed that the increased expression levels of TLR4 mRNA in PBMC from the Gram negative infectious patients are associated with Gram negative infections and the detection of TLR4 mRNA expression may be a method of diagnosis for Gram negative infections in the early stage.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Immunology
Year:
1986
Type:
Article