Mild hypothermia on patients with massive hemispheric infarction / 中华神经科杂志

ABSTRACT

Objective To study the influence of mild hypothermia on blood glucose and blood lactate and intracranial pressure (ICP) of the patients with anterior circulation brain infarction (massive hemispheric infarction) and evaluate its clinical effects.Methods All 30 patients with massive hemispheric infarction within the first 24 hours from stroke onset were randomly divided into the control group and the hypothermia group (15 patients respectively). To the latter group, mild hypothermia (32~34℃)was initiated and ICP values were measured in the same time. Rewarming was begun after hypothermic therapy lasted for 20~49(32?9)hours. In both groups, the blood glucose and blood lactate were measured at the time of admission, the second day and the fourth day. According to Neurological Deficit Scale score, the prognosis was evaluated at the time of admission and 4 weeks later.Results In hypothermia group, the initial ICP was (14.2?4.2) mm Hg, which was significantly reduced under hypothermia to (11.3?2.8) mm Hg(P