Comparison of the effects of glimepiride and glibenclamide on neuropeptide Y secretion from hypothalamus in diabetic KK-Ay mice / 中华内分泌代谢杂志

ABSTRACT

Diabetic KK-Ay mice were given glimepiride (GM) and glibenclamide (GB). After treatment, the visceral white fat content, insulin and hypothalamic neuropeptide Y (NPY) levels were significantly lower in GM group than those in GB group, suggesting that in addition to the lower insulin level stimulated by GM, the lower concentration of hypothalamic NPY seems to play a role in lessening increase in body fat of type 2 diabetic animals treated with GM.