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The reversal effect of tamoxifen on the expression of MDR1 in pancreatic cancer / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery ; (4)1999.
Article in Chinese | WPRIM | ID: wpr-541095
ABSTRACT

Objective:

To study the reversal effect of tamoxifen(TAM)on the expression of mdr1 in human pancreatic cancer cell lines.

Methods:

The inhibtion effect of TAM on pancreatic cancer cell line SW1999、Capan-Ⅱ and mammary cancer cell line T47D were studied;The influence of TAM on mdr1 protein/mRNA expression in SW1999、Capan-Ⅱ and T47D were studied using the method of flow cytometer and RT-PCR.

Results:

The high dose TAM could inhibit Capan-Ⅱ cell line.TAM could reverse the expression of mdr1 protein and mRNA in Capan-Ⅱ cell line and T47D cell line.

Conclusion:

The high dose TAM could inhibit Capan-Ⅱ cell line,maybe related with reduction of the expression of mdr1 protein and mRNA.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Current Advances in General Surgery Year: 1999 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Current Advances in General Surgery Year: 1999 Type: Article