Cardioprotective effect of trimetazidine in elderly patients with coronary artery disease / 中华老年医学杂志

ABSTRACT

Objective To evaluate the cardioprotective effect of trimetazidine in elderly patients with myocardial ischemia and chronic heart failure of coronary artery disease. Methods Eighty nine patients with angiographically proven coronary artery disease were randomized to therapy group (n=45) and controlled group (n=44). The patients in therapy group were given both the routine treatment and trimetazidine 20 mg, 3 times daily, for 6 months. The patients in controlled group were given only the routine treatment. Results After the therapy, the episode of angina pectoris every week was fewer and weekly consumption of nitroglycerin tablets was less in patients of therapy group than those in controlled group (3.0?1.7 )episodes/w vs (3.9?2.1 )episodes/w,P0.05). Work load were increased 〔(10.2? 2.2) vs( 9.3 ?1.7)METs, P