The effects of EPO on immunofunctions in patients with chronic renal failure / 中国免疫学杂志

ABSTRACT

Objective:To investigate the effect of EPO on humoral and cellular immunity and the monocyte antigen presenting function in patients with chronic renal failure(CRF).Methods:60 patients with CRF were divided into three groups.Group A patients accepted hemodialysis and treated with EPO.Group B patients treated with EPO and didn't accept hemodialysis.Group C patients didn't accept EPO treatment and hemodialysis.After 8 weeks treatment,the subpopulations of T lymphocyte were analyzed with detected by flow cytometry analysis method;Immunoglobulins were measured with radioactive immuntzation method.In addition,the infection rate of patients with CRF in every group was compared.Results:The parameters of immune functions of patients with CRF were comparable between groups before treatment.After treated with EPO for 8 weeks,RBC numbers and Hb were significantly increased in patients of group A and group B,but not in patients of group C.IgG and IgA were increased in patients of groups A and groups B and have statistic differences as compared with that in patients of group C(P