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The Role Of Tumor Marker CA 15-3 In Detection of Breast Cancer Relapse After Curative Mastectomy / 대한핵의학회잡지
Korean Journal of Nuclear Medicine ; : 311-317, 2004.
Article in Korean | WPRIM | ID: wpr-54168
ABSTRACT

PURPOSE:

The purpose of this study was to determine the utility of tumor marker CA 15-3 in the following the diagnosis of breast cancer relapse after curative mastectomy, and the differentiation of the value of tumor marker by site of metastases. MATERIALS AND

METHODS:

Two hundred two patients (median age 48 years) with breast cancer included in the follow-up after curative mastectomy. The tumor marker CA 15-3 was determined by IRMA (CIS BIO INTERNATIONAL, France). Test values > 30 U/ml were considered elevated (positive).

RESULTS:

Among 202 patients, recurrent diseases were found in 16 patients. CA 15-3 was elevated in 5 of 16 patients with recurrences. There was no false-positive patient who had elevated CA 15-3. Sensitivity and specificity of CA 15-3 for detection of breast cancer recurrence were 31%, and 100%. CA 15-3 was elevated in all of the 4 patients with liver metastases. CA 15-3 was elevated in none of the patients who relapsed with metastasis to bone-only or contralateral breast-only.

CONCLUSION:

The tumor marker CA 15-3 in the detection of breast cancer relapse after curative mastectomy is specific, but not sensitive. However, it is useful to rule out liver metastases of breast cancer, which indicates bad prognosis.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Recurrence / Breast / Breast Neoplasms / Follow-Up Studies / Sensitivity and Specificity / Diagnosis / Liver / Mastectomy / Neoplasm Metastasis Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: Korean Journal: Korean Journal of Nuclear Medicine Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Recurrence / Breast / Breast Neoplasms / Follow-Up Studies / Sensitivity and Specificity / Diagnosis / Liver / Mastectomy / Neoplasm Metastasis Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: Korean Journal: Korean Journal of Nuclear Medicine Year: 2004 Type: Article