Clinical significance of fatty acid synthase in non-small cell lung cancer / 中国癌症杂志

ABSTRACT

Purpose:To explore the expression of fatty acid synthase in non-small cell lung cancer and to detect its association with clinicopathological features and prognosis.Methods:107 patients with NSCLC who underwent surgery were followed up for more than 5 years.Fatty acid synthase were evaluated by immunohistochemisctry on formalin fixed paraffin embedded tissues and compared with benign lesion and normal tissue.Multiple clinical parameters and survival were analyzed.Results:In 107 patients with NSCLC,FAS expression was observed in 43 cases(40.2%).In contrast to benign lesions and normal tissue,FAS is significantly overexpressed in NSCLC.Survival analysis revealed that the 5-year survival rate was lower in FAS positive patients than in negative patients(16% vs 43%,p