Mutations in the D-loop region of mitochondrial DNA in gastric cancer / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery
;
(4)2004.
Article
in Chinese
| WPRIM
| ID: wpr-542003
ABSTRACT
Objective:
To investigate the variations o f mitochondrial D-loop region in gastric cancers.Methods:
The D-loop region of 12 gastric cancers together with th e adjacent normal tissues were amplified by PCR and sequenced.Results:
Among the 12 cases,16 mutations and 28 polymorphisms were identified with the mutations rate of 50%.There were 3 new polymophisms which we re not reported previously in the GeneBank among the 28 polymorphisms.Conclusion:
We think that the mitochondrial DNA D-loop region is a highly polymorphric and mutable region and the mutation rate is relatively high in patients with gastric cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Current Advances in General Surgery
Year:
2004
Type:
Article
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