Change of Bone ?-Carboxyglutamic Acid Containing Protein in the Serum of Rats at the Initial Stage of Skeletal Fluorosis Caused by Fluoride in Coal / 环境与健康杂志

ABSTRACT

Objective To study the change of bone ?-carboxyglutamic acid containing protein(BGP) in serum of rats at the initial stage of skeletal fluorosis caused by fluoride in coal.Methods SD rats were randomly divided into 6 groups (the number of female and male in each group was the same respectively)the control group,the low-dose fluoride group,the middle-dose fluoride added nutrition group,the middle-dose fluoride group,the high-dose fluoride added nutrition group,the high-dose fluoride group.All rats in the experimental groups were fed on the corn collected from the prevalent areas and contained different contents of fluoride respectively for 90-100 days.Content of fluoride in the urine,bone,kidney,BGP in serum,bone mineral density (BMD)and calcium in the bone and urine were determined.Results The fluorosis of the rats became more serious as fluoride intake increased.On the condition of same fluoride intake,the fluorosis could be relieved if nutrients added.BGP in serum of rats in each experimental groups had a increase trend,at the earlier stage,BGP of the high-dose group was higher than that of the control group (P