Clinical biology value of p53 overexpression in Chinese breast cancer by Meta analysis / 中国癌症杂志
China Oncology
;
(12)2000.
Article
in Chinese
| WPRIM
| ID: wpr-542295
ABSTRACT
Purpose:
To find out the clinical biology value of p53 overexpression on Chinese breast cancer by Meta analysis.Methods:
Reviewed all the published studies during the recent 10 years regarding p53 and breast cancer, and used standard techniques of Meta-analysis to combine the results of these studies to produce a more precise estimate of the prognostic significance of p53 mutations.Results:
the mean of p53 positive express was 45%,95% confidence interval (43-47)%, p53 positive was related with node metastasis, recurrence after surgery, over survival, tumor size and nuclear grade, but not related with age and pathology type, p53 was a special and sensitive prognostic factor for breast cancer.Conclusions:
p53 can be an independent molecular marker to definitive prognostic of breast cancer, and possibly can be a reliable marker for choice of standard and individulized therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
/
Systematic reviews
Language:
Chinese
Journal:
China Oncology
Year:
2000
Type:
Article
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