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Preliminary observation on the effects of implantation of BMSCs-root-CHA complex in dog / 实用口腔医学杂志
Article in Zh | WPRIM | ID: wpr-542464
Responsible library: WPRO
ABSTRACT
Objective:To evaluate the periodontal tissue regeneration effect of implantation of bone marrow stromal cells(BMSCs)-root-coralline hydroxyapatite(CHA) complex.Methods:BMSCs of beagle dogs were in vitro cultured on CHA scaffold and on tooth root surface respectively.Then BMSCs-root samples were inserted into BMSCs-CHA scaffolds to form BMSCs-CHA-root complexes.5 complexes were implanted on one side of mandible in each of the dogs 1 month after the 4th,5th and 6th teeth had been extracted.Root-CHA without BMSCs was implanted on another side as the control.All dogs were killed 16 weeks after implantation,and the periodontal tissue regeneration were observed histologically.Results:More new bone formation and more mature alveolar bone were observed in the test group than that in the control,and there was a clearly periodontal ligament-like tissue formation only in the test group.Conclusion:The complex of BMSC-root-CHA can improve the periodontal tissue regeneration.
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Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Practical Stomatology Year: 2001 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Practical Stomatology Year: 2001 Type: Article