The histopathologic features of rat bladder with capsaicin intravesical instillation / 中华泌尿外科杂志

ABSTRACT

0.05).Morphology showed slight dilation of the vessels in the superficial part of lamina propria in the 100 ?mol/L capsaicin group.In the group treated with 2 mmol/L capsaicin,erosion of the mucosa,edema and capillary distention in the lamina propria were seen as well as focal damage to the superficial muscle near the lamina propria.This led to hematuria in the early stage.The mucosal changes started to heal after 1 week and returned to normal after 8 weeks.Conclusions In rats,intravesical capsaicin instillation at a dose of 100 ?mol/L appears to be a safe method of treatment.High doses of capsaicin may result in some reversible damages of the mucosa and inflammatory changes of the bladder.