Quantitative Studies of Diffusion Weighted Imaging Using 3.0T MR in Rat C6 Glioma Models / 实用放射学杂志

ABSTRACT

Objective To study the average ADC and eADC values in the C6 glioma regions and the contralateralnormal caudate nucleus of rat C6 glioma models on 3.0Tesla MR.Methods 32 healthy male Sprague-Dawley rats, weighted 250~300 g, were injected with C6 cells in right candate nucleus. All subjects were examined with MR imaging, including conventional and diffusion-weighted imaging with two b values ( 0 and 1000 s/mm~2 ) at 3.0T . ADC and eADC values were determined on ADC and eADC maps . Results The average ADC values in the C6 glioma regions and the contralateral normal caudate nucleus were(0.805?0.12)?10~ -3 mm~2/s and( 0.666?0.13 )?10~ -3 mm~2/s respectively ; the average eADC values in the C6 glioma regions and the contralateral normal caudate nucleus were (0.451?0.06) and (0.519?0.08) respectively. The difference of average ADC and eADC value between C6 glioma region and the contralateral normal caudate nucleus is significant. Conclusion It is feasible to do DWI in rat C6 glioma model with 3.0T MR and the ADC and eADC values measured in C6 glioma model can be used for reference in future studies.