THE PREVENTIVE EFFECT OF SCOPOLAMINE HYDROBROMIDE ON ACUTE RENAL FAILURE IN RABBITS / 解放军医学杂志

ABSTRACT

This paper deals with preventive effect of scopo-lamine hydrobromide in glycerin induced acute re-nal failure in rabbits. 24 hours after glycerin injection, the renal flow of controls was reduced 65%, while that of animals which received scopolamine was only reduced 33.5%. The level of angiotensin Ⅱ in the controls was increased during ARF, while that of the test group was not significantly higher than normal 24 hours after ARF. The results of FENa and RFI determination demonstrated that the drug had protective effect on the tubular Na reabsorption function.