Your browser doesn't support javascript.
loading
Effects of interleukin-18 on transdifferentiation in renal tubular epithelial cells / 中国免疫学杂志
Chinese Journal of Immunology ; (12)1986.
Article in Chinese | WPRIM | ID: wpr-542920
ABSTRACT

Objective:

To study the effect of interleukin-18 on transdifferentiation in renal tubular epithelial cells(TECs).

Methods:

Human proximal tubular epithelial cell line(HK-2) was cultured in vitro.TECs were exposed to different concentrations(0,0.1,1,10 and 100 ng/ml) of IL-18 for 24,48 and 72 hours.At the end of each incubation,the expressions of the ?-SMA and TGF-?_1 mRNA were assessed by RT-PCR,the rate of ?-SMA expressing TECs was assessed by immunocytochemistry,and the expression of the ?-SMA protein was assessed by Western blotting.

Results:

(1)The expressions of ?-SMA and TGF-?_1 mRNA were increased significantly by a dose- and time-dependent manner when TECs were exposed to IL-18(P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Immunology Year: 1986 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Immunology Year: 1986 Type: Article