Research on HRCT-Pathologic Correlation of Alveolitis Induced by Pneumococcus and Bleomycin / 实用放射学杂志

ABSTRACT

Objective To investigate the image profiles and pathological manifestations of lung damages induced by Bleomycin(BLM) or pneumococcus,and to further elucidate the characteristic image profiles and its pathologic basis of pulmonary fibrosis.Methods 90 SD ratswere divided randomly into BLM group,pneumonia group and control group,the models were made by intratracheal instilling of BLM,pneumococcus and saline respectively.At the different time,HRCT scans were performed in all rats.The pulmonary specimens of rats were observed on pathology.Results Images of concentrated density in lung was observed in both BLM and pneumonia groups in early stage.In BLM groups,the areas of concentrated density image mainly surrounding main bronchus,were larger than that of pneumococcal pneumonia groups.And the images of fibre were seen in lungs of BLM-treated rats in 7 days.The correlation-observation of pathology showed,a lot of neutrophil and macrophages infiltrating in lungs of both groups,with a lot of exudates in the alveolus in pneumococcal pneumonia groups.Otherwise,the hyperplasia of fibroblasts was observed in the lung interstitium in the 5-7 day groups treated by BLM.Conclusion The imaging findings of alveolitis caused by BLM is of some different characteristic in comparison with that caused by pneumococcus.