Value of Serum Thyroglobulin in Diagnosis and Treatment of Differentiated Thyroid Cancer Patients / 中国普外基础与临床杂志

ABSTRACT

Objective To discuss the value of thyroglobulin (TG) in diagnosis and treatment of differentiated thyroid cancer (DTC) patients. Methods Literatures on measurement and clinical application of serum TG were reviewed. Results Immunometric assay (IMA) was adopted by most clinical lab.TG antibody (TG-Ab) should be measured in the same sample of DTC patient.TG detection before operation is of less value in confirming diagnosis of DTC, but is helpful in differential diagnosis of histopathological type of DTC.TG detection after operation is very important in patients who had undergone total thyroidectomy.Monitoring TG after thyroid hormone withdrawal or recombinant human TSH stimulation is more sensitive to identify tumor recurrence. Conclusion Monitoring TG after total thyroidectomy has great value in follow-up of DTC patients.