Study on the Genotoxicity of Organic Extracts From Fishpond Water Containing Sewage / 环境与健康杂志

ABSTRACT

Objective To evaluate the genotoxicity of the organic extracts in the fishpond water containing the sewage. Methods Healthy Kunming mice were randomly divided into 6 groups according to the body weight, 8 mice in each group. The mice were treated with organic extracts through intraperitoneal injection at the doses of 25 L/kg, 12.5 L/kg, 6.25 L/kg, 3.125 L/kg water sample respectively for 3 consecutive days. Genotoxicity induced by organic extracts from the fishpond water containing the sewage was detected by the mice bone marrow micronucleus test and un-fluorescent staining comet assay of mice peripheral blood lymphocytes. Results The frequencies of the micronuclei in PCE cells of mice in the 25 L/kg and 12.5 L/kg groups of the sample were significantly higher than those of the negative control group(P