Effects of As_2O_3 on Expression of NF-?B p65,Survivin and Caspase-3 in Human Breast Cancer / 中国普外基础与临床杂志

ABSTRACT

Objective To investigate the effects of As_2O_3 on expression of NF-?B p65, survivin and caspase-3 in human breast infiltrating duct carcinoma xenograft model on nude mice. Methods A human breast infiltrating duct carcinoma model on nude mice was established and the nude mice were divided randomly into three groups control group, DDP group and As_2O_3 group (1.5 and 3.0 mg/kg concentrations). The expression of survivin mRNA was detected with the method of in situ hybridization and the expressions of NF-?B p65, survivin and caspase-3 protein were measured with immunohistochemistry. Results The positive rates of NF-?B p65 and survivin expression were higher in the control group than those in the DDP group and the As_2O_3 groups, but that of caspase-3 was on the opposite way (P