Two different types of malignant fibrous histiocytomas from pet dogs
Journal of Veterinary Science
;
: 169-171, 2009.
Article
in English
| WPRIM
| ID: wpr-54361
ABSTRACT
We describe 2 cases of malignant fibrous histiocytomas (MFHs) that spontaneously developed in young pet dogs. To classify these tumors, we applied a panel of antibodies (vimentin, desmin, alpha-SMA, and ED1) and Azan staining for collagen. The MFHs were most consistent with osteoclast-like giant and inflammatory cell types. The first case had positive staining for ED1 and vimentin, and given the osteoclast-like giant cells, calcification sites accompanying peripheral giant cell infiltrates. The latter case, the inflammatory cell type, exhibited a storiform-pleomorphic variant of neoplastic cells, including an ossifying matrix. MFHs are among the most highly aggressive tumors occurring in soft tissue sarcomas in elderly dogs; however, MFHs have been poorly studied from a diagnostic point of view. Herein, we describe the histologic and immunohistologic features of MFHs in detail, thus classifying the subtypes of these tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Soft Tissue Neoplasms
/
Biopsy
/
Immunohistochemistry
/
Dog Diseases
/
Histiocytoma, Malignant Fibrous
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2009
Type:
Article
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