Expression and clinical significance of PTEN and Caspase-3 in esophageal squamous cell carcinoma / 西安交通大学学报(医学版)

ABSTRACT

Objective To study the expression of PTEN and Caspase-3 proteins in esophageal squamous cell carcinoma(ESCC) and to analyze the relationships between the expressions of the proteins and clinicopathologic factors as well as prognosis.Methods 64 cases of ESCCs,16 cases of pericarcinoma tissues and 16 cases of dysplasia epithelium were immunohistochemically stained.All 64 patients who underwent surgical treatment up to January 2005 were regularly followed up through letters and check-ups.Results The positive expression rate in pericarcinoma tissues,dysplasia and ESCC were significantly down-regulated((P