A Case-Control Study on the Relationship Between Environmental Risk Factors Exposed in Early Pregnancy and Congenital Heart Disease / 环境与健康杂志

ABSTRACT

Objective To understand the effect of environmental risk factors exposed in the first trimester of pregnancy on congenital heart disease, then provide scientific evidence for congenital heart disease prevention. Methods A hospital-based 11 matched case-control study was conducted. The risk factors were obtained by field investigation with standardized questionnaires. The data was dealt with single factor analysis and conditional Logistic regression using SPSS version 11.5. Results Folic acid(OR=0.340, 95%CI 0.178-0.649), milk(OR=0.660, 95%CI 0.460-0.947), meat(OR=0.771, 95%CI 0.583-0.867) and nausea and vomiting of pregnancy(OR=0.457, 95%CI 0.271-0.770)were significantly associated with congenital heart disease. Maternal infection(OR=2.736, 95%CI 1.462-5.121), taking medicine(OR=2.735, 95%CI 1.483-5.044), poisonous chemicals(OR=2.764, 95%CI 1.065-7.177) and mental stress(OR=2.211, 95%CI 1.022-4.782) were risk factors of congenital heart disease. Conclusion To prevent congenital heart diseases, pregnant women should take more nutriment, keep healthy state and avoid infecting, taking medicine and exposing chemical toxicants in the first trimester of pregnancy.