Comparison of two osteoarthritis models in rabbit / 中国矫形外科杂志

ABSTRACT

[Objective]To establish osteoarthritis model in rabbit knees by two kinds of surgery methods,and to explore their applicable conditions.[Method]Seventeen rabbits were divided into three groups(Hulth group,ligament-excised group and control group),they were anesthetized and operated differently according to their group.The rabbits were sacrificed at 1,3 and 6 weeks after surgery.The femoral condylars were harvested and studied in both gross morphological and pathohistological aspect.[Result]The degeneration of articular cartilage of the two surgery groups got worse by time,and their Mankin's scores were significantly higher than those in the control group(P