Expression of AP-1 subunits in skin tumor and its significance / 中国癌症杂志

ABSTRACT

Purpose:AP-1(activator protein-1) is closely associated with cell differentiation,proliferation,apoptosis and tumorigenesis.We investigated the expression of AP-1 subunits in skin tumor and its adjacent skin tissue and their roles in the occurrence and development of skin tumor.Methods:ABC immunohistochemistry was applied to detect c-jun,p-c-jun,JunB,JunD,c-fos,Fra-1,and Fra-2 expression in skin basal cell carcinoma,squamous cell carcinoma,Bowens disease and keratacanthoma.Results:The expression of c-jun and p-c-jun were increased dramatically in basal cell carcinoma,squamous cell carcinoma,Bowens disease and keratacanthoma and JunB was decreased sharply in basal cell carcinoma.Conclusions:c-jun is a positive regulator of cell proliferation and tumorigenesis in skin.JunB has an antagonistic function for c-jun.