Expression of apoptosis inhibision protein, Survivin,P53,and HPV in cervical carcinomas / 中国癌症杂志

ABSTRACT

Background and purpose:Survivin,a member of the inhibiter of apoptosis gene family,has been detected in fetal tissue and in variety of human malignancies.In the current study,we not only investigated the expression of a novel inhibitor gene of apoptosis,survivin in Cervixneoplasms but also studied its relationship between the expression of P53 and HPV-16. Methods:Using streptavidin-bintin peroxidase(SP)method,We examinined the expression of the proteins survivin , p53 and HPV-16 in 21 normal cervical tissues ,33 CIN and 72 cervical cacinoma tissues.Results:Survivin was expressed in 52 of 72(72.2%) cases of cervical carcimomas ,however,it was not expressed in normal cervical tissues and it was expressed in6 of 33(18.18%)cases of CIN. Overexpression of survivn was related to the tumor grade and clinical stage.Survivin positive cases were strongly associated with p53 expression (P