Simvastatin effect on inhibiting of the production of serum IL-6 and promotion the regeneration of sciatic nerve of rats / 中国矫形外科杂志
Orthopedic Journal of China
;
(24)2006.
Article
in Chinese
| WPRIM
| ID: wpr-544317
ABSTRACT
[Objective]To study the effect of Simvastatin on the regeneration of sciatic nerve of rats and its mechanism of immunoregulation.[Method]Twenty eight female Sprague-Dawley rats were used and the rats experienced the sciatic nerve crush injury.Animals were randomized into Simvastatin-treated crush injury animals,vehicle-treated crush injury animals and sham-operated animals.Simvastatin(20 mg/kg) was given once a day over a time period of 14 day sby oral gavage via a pharyngeal tube.After surgery,the functional evaluation of nerve recovery,electrophysiologic assessment,histological assessment,serum IL-6 and TNF-? assessment were performed.[Result]The toe spread index of Simvastatin-treated crush injury animals was higher significantly than that of vehicle rats at d5 and d8(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Orthopedic Journal of China
Year:
2006
Type:
Article
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