The inhibitory effect of elemene combined with tamoxifen on the breast cancer MCF-7 cell line / 西安交通大学学报(医学版)

ABSTRACT

Objective To explore if elemene can synergize tamoxifen through using non-cytotoxic dose of elemene and tamoxifen in combination on MCF-7cell line of breast cancer.Methods First,MCF-7 cell line was cultured in RPMI1640.Then,TAM's inhibitory effect united with elemene on MCF-7 cell line was analyzed by using CCK-8 test.Results When adding non-cytotoxic dose of elemene and curative dose of tamoxifen into the two experimental groups,the absorptivity in the two groups reduced notably,compared with that of the groups using tamoxifen alone;accordingly,the inhibition rate in two mixing groups increased obviously compared with that in single-drug groups.Conclusion Elemene of innocuous dose can remarkably enhance the inhibitory effect of tamoxifen,which indicates that elemene may synergize the effect of tamoxifen on breast cancer.