The influence of Xinfeng capsule on pulmanory HRCT images and cytokines in blood serum of adjuvant arthritis rats / 中国免疫学杂志

ABSTRACT

Objective:To observe the influence of Xinfeng capsule(XFC) on pulmonary HRCT images and cytokines(TNF-?,IL-10) in blood serum adjuvant arthritis rats.Methods:60 rats were averagely divided into normal control group,model control group,methotrexate(MTX) treated group,tripterygium wilfordii polycoride tablet(TPT) treated group, XFC treated group,12 in each.Except for the rats of normal group,the others were intracutaneously injected with 0.1 ml of Freund’s complete adjuvant in the right hindlimb.After 19 days,different drugs were given to all rats. Pulmonary HRCT images were obtained and the blood samples were reserved for assaying cytokines.Results:In model control group ,the lungs’ outlines weren’t clear and the blood vessels expanded with the edges of them being obscure and unregular. There were high density images shaped as rope and slip in lungs of model control group rats and the pleura near the images were a little thickening. In MTX treated group, there were high density images shaped as slice along pulmonary veins. The veins of the blood vessels were obscure and the edges were unclear. In TPT treated group,there were multiple high density images shaped as tubercle and slice and the boundary were not clear. In XFC treated group, the lungs’ outlines were clear and the veins were well-distributed. High density images shaped as spot were found in part lungs. Compared with normal control group,tumor necrosis factor-?(TNF-?) in blood serum ascended obviously in model control group(P0.05).Conclusion:XFC eliminates swelling by down-regulating the levels of TNF-?, up-regulating the levels of IL-10, restraining the inflammatory reaction.In adittion,cytokines participated in forming pulmanory fibrofication.So the changes of pulmanory HRCT images were also improved at the same time.