The role of bFGF in vascular injury of BLM-induced pulmonary fibrosis / 西安交通大学学报(医学版)

ABSTRACT

Objective To explore the expression of basic fibroblast growth factor(bFGF) in pulmonary tissues of rats with bleomycin-induced pulmonary fibrosis and the role of bFGF in vascular injury.Methods Pulmonary fibrosis was induced in rats by intratracheal injection of bleomycin(BLM).Lung expression of bFGF proteins was assessed by SABC immunohistochemistry using bFGF monoclonal antibody and quantitative image analysis.Results The expression of bFGF in the lung tissues of BLM group was mainly distributed in bronchiole epithelial cells,muscular layers of bronchi and arterioles,and alveolar macrophage.It was higher than that in control group,with significant difference(P