The expression of focal adhesion kinase and Ki67 in invasive breast ductal carcinoma and their clinical significance / 中国免疫学杂志

ABSTRACT

Objective:To investigate the expression of focal adhesion kinase(FAK) and Ki67 in the invasive breast ductal carcinoma tissues, seeking their relationship with tumor invasion and metastasis and to study the mechanisms for cell signaling transduction mediated by FAK in the carcinogenesis and progress of breast carcinoma.Methods:Tissues were obtained from 88 patients with invasive breast ductal carcinoma and 25 with breast ductal epithelial benign proliferative disease. The expression of FAK and Ki67 was examined by immunohistochemical technique(streptavidin peroxidase conjugate method, SP).Results:In 88 cases of invasive breast ductal carcinoma, the positive incidences of FAK was 68.2%(60/88), and the Ki67 proliferation index was 29.6%?22.9%, which distinguished apparently to those of the control group(P0.05). In breast carcinoma tissues, the expression of FAK was positively related to Ki67 proliferation index(P