The comparasive study on the immunizing efficiencies among differently inoculated routes with recombinant adenovirus expressing rotavirus VP4 antigen / 中国免疫学杂志
Chinese Journal of Immunology
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-545185
ABSTRACT
Objective:
To compare the immunizing efficiency in mice with recombinant adenovirus inoculated by intranasal, intramuscular or oral routes.Methods:
BALB/c mice were immunized with 108 PFU recombinant adenovirus expressing rotavirus VP4 antigen intranasally, intramuscularly or orally.The mice were boosted twice with the same dose by the same route. Serum, stool and intestine specimens were collected to detect rotavirus VP4 specific antibodies by ELISA. Mice were mock treated with adenoviral vector and PBS as the blank control.Results:
Inoculation with the recombinant adenovirus by these 3 routes elicted rotavirus VP4 specific serum and intestinal antibodies(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2001
Type:
Article
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