Detection on the expression of PKC-? protein in lung cancer by tissue microarray / 中国癌症杂志
China Oncology
;
(12)2006.
Article
in Chinese
| WPRIM
| ID: wpr-545397
ABSTRACT
Background and purpose:
Protein kinase C (PKC) is a potentially important target for cancer therapy due to its potential role in carcinogenesis. Abnormal expression and increasing activity of PKC-?are present in non-small cell lung cancer (NSCLC).The aim of this study is to investigate PKC-? protein expressions in lung cancer tissues by tissue microarray and their significance.Methods:
Using tissue microarray, PKC-? protein expression in lung cancer patients was examined by immunohistochemistry. 182 samples of umor tissues and 18 samples of adjacent tissues were taken;of the 182 samples, 160 were NSCLC tissues and 22 were SCLC;102 samples from stage I cases and 58 from stageⅡ-Ⅲ cases.Results:
Expression of PKC-? protein was observed in 48.3% (88/182) of cancerous tissues and 16.7% (3/18) of adjacent tissues (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
China Oncology
Year:
2006
Type:
Article
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