MR Imaging of Short-term Expansion of Bone Marrow Haemopoiesis In Vivo / 实用放射学杂志

ABSTRACT

Objective To study MR imaging features of bone marrow after priming.Methods 11 cases with lymphoma or myeloma alleviated after treatment were administration of recombinant human granulocyte colony-stimulating factor(rhG-CSF)injection.Two regions of bone marrow in L3 and iliac were followed up with T1WI,and STIR fat saturation before treatment(0 week),and 1 week,2 weeks and 4 weeks after treatment respectively.MRI features were observed by three experienced doctors independently and the average results acted as the final result.In the meantime,CNR of marrow and fat were calculated and paired sample test.Statistical process was performed in SPSS 10.0 for Windows.Results In comparison with 0 week,the signal intensity of bone marrow was no changed in all cases one week after intensive chemotherapy,slight high in 5 cases 2 weeks later and obvious low signal intensity in all cases three weeks after priming with rhG-CSF.In comparison with 0 week,CNR was no any different significance at 1 week,2 weeks and 4 weeks.Bone marrow changes in lumber and iliac were parallel except one case at 2 weeks and one case at 4 weeks.Conclusion Obvious low signal intensity of bone marrow is found three weeks after priming with rhG-CSF.