Deactivation Network of Parametric Digit n-back Working Memory Task in Normal Subjects:An fMRI Study / 中国临床心理学杂志

ABSTRACT

Objective: To explore task induced deactivation(TID) brain regions in WM task and its significance.Methods: 35 normal subjects receiving fMRI with a parametric digit n-back task(n=1,n=2,n=3 task) were employed,with an 0-back control condition.On the basis of behavioral performance of 3 back task in experiment,normal subjects whose accuracy exceeding or equal to 85% were included in high performing normal subjects(HPNS) group.Preprocessing,statistical analysis and result display of functional data were performed by SPM2.Results: For HPNS,task induced deactivation brain regions included medial prefrontal cortex(MPFC),cingulate,right inferior frontal gyrus(BA47),multiple regions in bilateral temporal lobe.Within the scope of 2back load level,deactivation of TID brain regions increased with increasing load,and most TID regions showed platform manifestation once the 2back level was exceeded.Conclusion: TID network is essential for accurate performance of WM.