Primary research on the influence of trabeculectomy on tear film and epithelial cells of ocular surface / 中华显微外科杂志

ABSTRACT

Objective To investigate the early influence nf trabeculectomy on tear film and epithelial cells of ocular surface.Methods Twenty-six patients (36 eves) with glaucoma underwent trabeculectomy with adjustable suture,and with or without use of intraoperative mitomycin-C(MMC) undel conjunctiva and sclera were included from March 2006 to May 2007.Routine ocular examinations and ocular surface examina- tions,including Schirmer I test,break-up time,fluorescein staining,rose bengal staining,and conjunctival impression cytology,were conducted preoperatively and 1 month postoperatively.Results Compared with normal controls,troth postoperative and preoperative BUT were significantly shortened,and FL,RB scores, conjunctival Nelson classification significantly higher,and goblet cell density was significantly decreased in glaucomatous patients.No statistically significant difference of Sit were observed between the patients and the normal controls.There were no statistically significant difference of Sit,BUT,FL and RB scores between pre- operation and 1 month postoperation.Postoperative conjunctival Nelson classification was significantly higher than preoperative level,and goblet cell density was significantly lowered.There were no significant difference of Slt,BUT,Nelson classification and goblet cell density between 0.25 mg/ml MMC group and the control preoperatively and 1 month pnstoperatively.The FL and RB scores of the control group were significantly high- er than MMC group postoperatively.Conclusion There may be some influence of trabeculectomy on tear film stability and ocular surface epithelium,which is manifested by teat film unstability,epithelial staining, conjunctival squamous metaplasia,and goblet cell density decrease 1 month postoperatively.These may not be related to use of low concentration of MMC in operation.