Bone defect repair using allogenic ECM combined with chondrocytes in rabbits / 中国矫形外科杂志
Orthopedic Journal of China
;
(24)2006.
Article
in Chinese
| WPRIM
| ID: wpr-545706
ABSTRACT
[Objective]The characteristics and mechanism of the bone defect repair with the using allogenic extracellular cartilage matrix(ECM)were studied.[Method]Forty New Zealand white rubbits were divided into three groups at randomA and B on the right side,the defect was covered with the complex of ECM and autologous mesenchymal stem cells(MSCs),the ECM in the groups A and B,respectively.The defects on the left side served as controls correspondingly.The rabbits were killed at the 2nd,4th,6th,10th week.Samples were taken for radiological and histological studies.[Result]In the experimental sides the bone defects were healed.New bone appeared in the way of intramembranous ossification and entochondrostosis.[Conclusion]It is suggested that the complex of ECM and autologous MSCs has the effects on guiding bone regeneration and preventing from nonunion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Orthopedic Journal of China
Year:
2006
Type:
Article
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