Role of the Peripheral Vestibular System on Neuroplasticity Induced by Hypergravity Stimulation
Journal of the Korean Balance Society
;
: 213-223, 2006.
Article
in Korean
| WPRIM
| ID: wpr-54602
ABSTRACT
BACKGROUND AND OBJECTIVES:
Altered environmental gravity, including both hypo- and hypergravity, may result in space adaptation syndrome. To explore the characteristics of this adaptive plasticity, the expression of immediate early gene c-fos mRNA in the vestibular system following an exposure to hypergravity stimulus was determined in rats. MATERIALS ANDMETHOD:
The animals were subjected to 2 G force (two-fold earth's gravity) stimulus for 3 hours, and were examined at post-stimulus hours 0, 2, 6, 12, and 24. Real time reverse transcription-polymerase chain reaction (RT-PCR) was adopted to analyze temporal changes in the expression of c-fos mRNA.RESULTS:
The hypergravity stimulation produced the expression of c-fos mRNA in the vestibular ganglion, medial vestibular nucleus, inferior vestibular nucleus, hippocampus, vestibulocerebellum, and vestibular cortex. The peak expression occurred at hour 6 in the animals hypergravity-stimulated for 3 hours. Bilateral labyrinthectomy significantly attenuated the degree of up-regulation in c-fos mRNA expression. MK-801, an NMDA receptor antagonist, also significantly attenuated the degree of up-regulation in c-fos mRNA expression.CONCLUSION:
These results indicate that the adaptive neuroplasticity in response to an altered gravity occurs in the vestibular-related organs in the central nervous system, in which peripheral vestibular receptors and NMDA receptors play an important role.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plastics
/
RNA, Messenger
/
Vestibular Nuclei
/
Up-Regulation
/
Central Nervous System
/
Dizocilpine Maleate
/
N-Methylaspartate
/
Genes, fos
/
Receptors, N-Methyl-D-Aspartate
/
Space Motion Sickness
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Balance Society
Year:
2006
Type:
Article
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