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Progress in CXCL12-CXCR4 biological axis in colorectal cancer / 中国癌症杂志
China Oncology ; (12)2001.
Article in Chinese | WPRIM | ID: wpr-546056
ABSTRACT
Colorectal cancer(CRC) is kind of the common malignant tumor worldwide.Bad prognosis is always due to distal metastasis.In recent years,the research on chemokines targeted on cancer metastasis and directing on the movement of the tumor cells have been more and more deeply taken into consideration.Chemokine CXCL12 and its specific chemokine receptor CXCR4 play important roles in CRC cell's targeted cancer metastasis and directing movement by signal transduction mechanism.Researches showed that it can inhibit the migration and invasion of the tumor through interception chemokine receptor CXCR4 by many ways.The studies of this signal may be a potential target sit for gene therapy.The aim of this review was to summarize the current knowledge of these researches.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Oncology Year: 2001 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Oncology Year: 2001 Type: Article