Research avancement of breast cancer and hypoxia-inducible factor-1 / 中国癌症杂志
China Oncology
;
(12)1998.
Article
in Chinese
| WPRIM
| ID: wpr-546151
ABSTRACT
The hypoxia-inducible factor-1(HIF-1) gene located on the long (q)arm 21-24 of chromosome 14, is composed of HIF-1? and HIF-1? subunits. HIF-1 promotes its target gene HRE to transcribe by binding to the element and then causes a series of responses of the cell to hypoxia. HIF-1 has been found to be overexpressed in breast cancer cell, and the expressions of HIF-1 level were correlated with the prognosis and prediction factors of breast cancer. As a cytokine, HIF-1 will be a new prognosis factor and a new target for the treatment of breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Oncology
Year:
1998
Type:
Article
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