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Effects of 2,5-hexanedione on Protein Kinase Contents in Rats Spinal Cord / 环境与健康杂志
Journal of Environment and Health ; (12)1992.
Article in Chinese | WPRIM | ID: wpr-546294
ABSTRACT
Objective To clarify the role of protein kinase A (PKA),protein kinase C (PKC) and cyclin dependent kinase5 (CDK5) in the alterations of neurofialments (NFs) in 2,5-hexanedione (HD) induced toxic peripheral neuropathies. Methods HD was administrated to male Wistar rats by intraperitoneal injection at doses of 200 or 400 mg/kg,once a day,for 8 consecutive weeks. The relative contents of PKA,PKC,p35 precursor and CDK5 in spinal cord were determined by using SDS-PAGE and Western Blotting. Results In the cytosolic fraction of spinal cord,the levels of PKA and PKC in 400 mg/kg group significantly increased (P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Environment and Health Year: 1992 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Environment and Health Year: 1992 Type: Article